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Semaglutide Pills: Its Dosage and  Guide to Its Treatment Initiation

Last updated on December 5, 2023


Semaglutide pills have emerged as a game-changing innovation in the realm of type 2 diabetes mellitus treatment. This oral medication not only stimulates insulin production but also concurrently lowers blood glucose levels, making it a promising solution for diabetic patients. Additionally, it retards the release of sugar into the bloodstream, facilitating weight management. Semaglutide pills belong to a class of drugs that offer well-documented cardiovascular benefits. By mimicking natural hunger-regulating hormones and slowing stomach emptying, they create a feeling of fullness and facilitate controlled dietary choices. These pills not only lower the risk of heart disease and the fatality rate in diabetic patients but also assist in managing atherosclerotic diseases and may reduce the risk of stroke by affecting blood pressure levels.

Despite the availability of injectable semaglutide, many patients find the oral option more convenient, especially if they have reservations about self-administering subcutaneous injections.

Exploring Glucagon-Like Peptide 1 (GLP-1):

Semaglutide pills are classified under glucagon-like peptide 1 (GLP-1) medications, known for their ability to stimulate insulin secretion while inhibiting glucagon release.

Proper Medication Usage:

To harness the benefits of semaglutide pills for type 2 diabetes management, a daily regimen is recommended. Commencing with the lowest dose of 3mg, patients can gradually increase it to 7mg after 30 days if stricter glucose control is needed. Further adjustments can be made by shifting to the 14mg dose after another month. Semaglutide pills come in three strengths: 3mg, 7mg, and 14mg. The optimal time to take them is 30 minutes before a meal, with a glass of plain water. It’s important to avoid taking other medications and vitamins within 30 minutes of ingestion and avoid any other drinks or beverages.

When to Initiate Semaglutide Pills:

As it is discussed earlier that semaglutide pills are used to treat Type 2 Diabetes Mellitus. A diagnostic test known as Hemoglobin A1C or HbA1C is used to diagnose diabetes in patients. It is a simple blood test that measure your average blood sugar levels over the past 3 months. When this test shows elevated blood sugar level then semaglutide pills are initiated by the healthcare provider.

Managing Side Effects:

While the likelihood of experiencing side effects with semaglutide pills is minimal, some common ones include nausea, vomiting, abdominal pain, constipation, blurred vision, dizziness, dysuria, and polyuria. Nausea typically diminishes over time, but any persisting or worsening side effects should prompt consultation with a healthcare provider.

Critical Precautions:

This Earth Day, turn in unneeded medication for safe disposal

Individuals using semaglutide should inform their doctors if an allergic reaction occurs. Those with conditions like diabetic retinopathy, kidney disorders, gastroparesis, pancreatitis, intestinal disorders, or gall bladder disease may require special care. While semaglutide is not sedative, strenuous exercise while taking this medication can lead to excessively low blood sugar due to sweating, resulting in drowsiness, dizziness, and lethargy. Consequently, activities demanding full attention, such as driving, should be avoided. Combining alcohol with this medication carries the risk of lowering blood sugar to dangerous levels.

If you have any trouble in breathing or swallowing or if you feel any lump or swelling in neck region or face any voice changes then quick consultation is must.

For individuals planning to conceive, those who are pregnant, or suspect pregnancy, consulting a doctor is essential due to potential pregnancy-related risks. Such consultations should occur two months before attempting pregnancy, as medication adjustments may be necessary. Breastfeeding mothers should also consult with their doctors regarding medication use.

Importance of Medical History:

Before prescribing semaglutide pills, a comprehensive medical history is mandatory. Certain medicines used for high blood pressure may interact with semaglutide and result in a sudden drop in blood pressure, leading to a medical emergency. Patients should also disclose any habits such as smoking, alcohol consumption, or the use of illicit drugs.


Semaglutide pills are not recommended for individuals with a personal or family history of thyroid tumors, specifically thyroid C cell tumors or medullary thyroid carcinoma (MTC). They are also contraindicated in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2).

Proper Medication Storage:

To maintain the efficacy and safety of semaglutide pills, they should be stored in a cool, dry place, out of children’s reach, and away from sunlight and moisture.